Activated protein C resistance, endogenous anticoagulants and coagulation parameters in recurrent pregnancy loss
نویسندگان
چکیده
منابع مشابه
Acquired activated protein C resistance caused by lupus anticoagulants.
Lupus anticoagulants (LA) can cause acquired activated protein C resistance (APC-R), but the clinical significance is unclear. To investigate thrombosis and acquired APC-R in patients with LA, we enrolled all 132 patients undergoing hypercoagulability testing with positive LA results and in whom APC-R (with factor V-deficient plasma) was performed during a 2.5-year period. Among 121 patients wi...
متن کاملMolecular Mechanisms of Recurrent Pregnancy Loss
Introduction: Pregnancy and health is the process in which the egg is fertilized and being able to survive. When pregnancy occurs under some conditions and the fetus is being at risk, it will lead to abortion that occurs involuntarily and spontaneously. Abortions that occur more than two or three times are called recurrent pregnancy loss (RPL). Various etiological factors involved in RPL, inclu...
متن کاملSoluble CD30 in Normal Pregnancy Pre-Eclampsia and Recurrent Pregnancy Loss
Background: Normal pregnancy is thought to be dependent on Th2 deviation, while Recurrent Pregnancy Loss (RPL) and Pre-eclampsia (PE) appear to be biased toward the Th1 immune response. It is believed that the soluble form of CD30 (sCD30) is an index of Th2 immune response or modulator of Th1/Th2 responses. Objective: The aim of this study was determination of the sCD30 level in RPL and PE pati...
متن کاملThrombinography shows acquired resistance to activated protein C in patients with lupus anticoagulants.
In patients with lupus anticoagulants (LA), acquired resistance to activated protein C (APC) is difficult to demonstrate with clot-based assays due to the presence of the anticoagulant. Via the conversion of a fluorogenic substrate (thrombinography), we monitored the complete process of thrombin formation and decay and its delimitation by the protein C system in eight consecutive LA-patients wi...
متن کاملCongenital resistance to activated protein C in patients with lupus anticoagulants: evaluation of two functional assays.
The R506Q mutation ("Factor V Leiden") is responsible for the resistance to activated Protein C (aPCR), that is evaluated by coagulation tests. Such tests cannot be used in patients with lupus anticoagulants (LAs), due to the interfering effect exerted by these antibodies on "in vitro" phospholipid-dependent coagulation tests. For this reason, assays have been developed to evaluate aPCR that ar...
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ژورنال
عنوان ژورنال: Journal of Turkish Society of Obstetric and Gynecology
سال: 2011
ISSN: 1307-699X
DOI: 10.5505/tjod.2011.99705